From the 1980s through the 2020s, Indian American women founded and led companies that reshaped major sectors of the technology economy. Jayshree Ullal built Arista Networks into a leading cloud infrastructure company, Payal Kadakia pioneered the subscription marketplace model through ClassPass, and Neha Narkhede co-founded Confluent to commercialize real-time data streaming. Their companies achieved significant scale, challenged established industry leaders, and attracted major public market valuations. Collectively, these achievements expanded expectations of who could build and lead transformative technology companies, establishing a powerful new model of female leadership in Silicon Valley.