Indian American researchers and physicians helped establish climate change as a public health challenge. Gaurab Basu reframed climate change through the lens of health equity, Seema Wadhwa led one of the nation’s most ambitious healthcare decarbonization initiatives at Kaiser Permanente, and Ramanan Laxminarayan advanced the One Health framework linking environmental degradation, antimicrobial resistance, and infectious disease. Together, their work integrated environmental policy, healthcare, and public health into a unified approach to climate resilience.